Corynebacterium Parvum: Applications in Experimental and by A. R. Prévot (auth.), Bernard Halpern (eds.)

By A. R. Prévot (auth.), Bernard Halpern (eds.)

In his advent to the Ciba origin Symposium on "Immunopotentia­ tion," Sir Peter Medawar said that, "for the prior 20 years the keep watch over of the immune reaction has been almost equated to immunosuppression as the nice objective of utilized immunology has been the transplantation of tissues," and that, "with the invention of tumor immunity-the point of interest of immuno­ logical keep an eye on has replaced from immunosuppression to immunpotentiation and correspondingly the nice prize of utilized immunology has develop into the preven­ tion and keep an eye on of malignant growth." Corynebacterium parvum is now univer­ sally well-known as being the main effective shortly identified immunopotentiator. C parvum is on the middle of virtually all papers provided at this convention and it's been analyzed from quite a few viewpoints: taxonomy, pharmacology, immunopotentiation, stimulation of host resistance to tumor invasion in experi­ psychological versions and in human therapeutics. just about all info mentioned during this quantity are unique and lately bought. The discussions have been spontaneous, stimulating, and hugely enriching, and the implications already confirmed and re­ ported listed below are in lots of respects distinct. Discussions on the convention printed many different elements which require extra exploration. Nonspecific immunopotentiation has strongly penetrated into immunology, immunopathology, and, lately, oncology. absolutely, this zone of analysis will witness vital advancements within the close to destiny. This publication bargains the 1st synthesis of shortly to be had wisdom and emphasizes destiny prospects.

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C. Table VI. 5) on GVH Lethality, Summary of Results .... a:: :-- I:>

D) The crude water-soluble starting material exerts a striking adjuvant effect on the production of antibodies to influenza virus in the rabbit, while the more purified substance does the same to a lesser degree, comparable, however, with that of Freund's complete adjuvant (H37Ra). Passing mention may finally be made of the activity of the less purified water-soluble substance from C. parvum, in comparison with the activity of killed whole bacterial cells from the same species, on the infection of adult CD-l mice with encephalomyocarditis (EMC) virus and adult Balb/c mice with the "plasma variant" of Moloney sarcoma virus.

Finally, the index of adjuvant activity on the production of antiinfluenza virus antibodies is the ratio of the hemagglutination-inhibiting titers in sera of rabbits immunized with the antigen plus the substance under test to the corresponding titers in rabbits immunized with antigen plus FlA. From these results it may be concluded that: (a) Both the crude and purified water-soluble substances from C. parvum enhance the appearance of antibody-producing cells in mouse spleen P. JoDes et al. 44 Table I.

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