Concepts, Clinical Developments, and Therapeutic Advances in by Kurt W. Kohn (auth.), F. M. Muggia (eds.)

By Kurt W. Kohn (auth.), F. M. Muggia (eds.)

Where do you start to appear for a up to date, authoritative article at the prognosis or administration of a specific malignancy? The few basic oncology textbooks are commonly old-fashioned. unmarried papers in really good journals are informative yet seldom complete; those are extra usually initial studies on a really restricted variety of sufferers. convinced common journals often post strong indepth studies of melanoma subject matters, and released symposium lectures are usually the easiest overviews to be had. Unfor­ tunately, those studies and vitamins look sporadically, and the reader can by no means ascertain whilst an issue of detailed curiosity can be coated. melanoma therapy and learn is a chain of authoritative volumes which target to fulfill this want. it really is an try and determine a severe mass of oncology literature protecting nearly all oncology issues, revised usually to maintain the assurance brand new, simply on hand on a unmarried library shelf or by way of a unmarried own subscription. we have now approached the matter within the following style. First, via dividing the oncology literature into particular subdivisions resembling lung can­ cer, genitourinary melanoma, pediatric oncology, and so forth. moment, by way of asking emi­ nent specialists in every one of those components to edit a quantity at the particular subject on an annual or biannual foundation. every one subject and tumor sort is roofed in a quantity showing usually and predictably, discussing present analysis, staging, markers, all types of remedy modalities, easy biology, and more.

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Studies of the effects of cisplatin indicated that the sensitivity of cell lines often correlates with DNA crosslink production. In some cases increased sensitivity was associated with a reduced rate of repair of interstrand crosslinks or DNA-protein crosslinks. There are exceptions however. One such exception, a cell line that was more sensitive than expected from the amount of DNA crosslinking, differed from related cell lines in that the cells tended to undergo lysis before DNA crosslinks could be repaired.

62. 63. 64. 65. 66. 67. 68. 69. 70. 71. induced by cis-diamminedichloroplatinum(II) in human normal and tumor cell lines. Cancer Res 41:3347-3351, 1981. Ducore JM, Erickson LC, Zwelling LA, Laurent G, and Kohn KW: Comparative studies of DNA cross-linking and cytotoxicity in Burkitt's lymphoma cell lines treated with cisdiamminedichloroplatinum(II) and L-phenylalanine mustard. Cancer Res 42:897-902, 1982. Plooy, ACM, van Dijk M, Berends F, and Lohman PHM: Formation and repair of DNA interstrand crosslinks in relation to cytotoxicity and unscheduled DNA synthesis induced in control and mutant human cells treated with cis-diamminedichloroplatinum(II).

The development of infectious peritonitis is a major potential complication of intraperitoneal chemotherapy [27]. While the risk of bowel perforation is less when treatment is administered through a surgicallyplaced indwelling catheter, the presence of this foreign body in a patient who requires frequent catheter manipulations will place the patient at risk for an infectious event. This fact is emphasized by our experience administering cytarabine by dialysis exchange every six hours for five days (total of 20 exchanges) [32].

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