Clinical Pharmacology of Anti-Epileptic Drugs by P. J. M. Guelen, E. van der Kleijn, U. Woudstra (auth.), Dr.

By P. J. M. Guelen, E. van der Kleijn, U. Woudstra (auth.), Dr. H. Schneider, Prof. Dr. D. Janz, C. Gardner-Thorpe M. D., H. Meinardi Ph. D., A. L. Sherwin Ph. D. (eds.)

"He who's faithfully analysing ... epi­ lepsy is doing way over learning epilepsy" Hughlings Jackson enhancing this famous assertion by way of Jackson, possible say at the present time: "He who's faithfully analysing anti-epileptic medicines is doing excess of learning anti-epileptic drugs". For those medications not just serve to avoid epileptic matches and hence improve the therapy of epilepsy, also they are powerful within the remedy of cardiac arrhythmias and trigeminal neuralgia. in addition, medical pharmacologists think about anti-epi­ leptic medicines as version medications in pharmacokinetics and pharmocodynamics, because trustworthy tools can be found for his or her choice and their results and aspect­ results could be outlined. The tools of estimating of gear in physique fluids offer a device that allows us to throw gentle on many vague relationships in pharmaceutical therapy. Now that we will be able to examine the pharmacokinetics and interplay of substances in guy, many hypotheses in accordance with medical adventure on my own may be eradicated or corroborated. The develop­ ing physique of data will make us extra cautious in regards to the management of substances together. Now that we will be able to learn how organic parameters intervene with drug motion, we may possibly continue to the medical research of many scientific observations that recommend the significance of such elements as age, intercourse, menstrual cycle, being pregnant, fever, vitamin, rigidity, recreation, weather, and altitude.

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27. : The kinetics of alcohol elimination in man. Acta pharmacol. ) 14, 265 (1958). 28. Mannering, G. : Biotransformation. In: Antiepileptic Drugs (eds. D. M. Woodbury, ]. K. Penry, R. P. Schmidt), p. 23. New York: Raven Press 1972. 29. Meijer, J. W. : Simultaneous quantitative determination of anti-epileptic drugs including carbamazepine, in body fluids. Epilepsia 12, 341 (1971). 30. Meijer, J. W. , editors: Methods of analysis of anti-epileptic drugs. ICS 286, Amsterdam: Excerpta Medica 1973.

Toxicological problems in drug combinations. Vol. XIII, p. 75. Amsterdam: Excerpta Medica 1972. Drug Interactions at the Metabolic Level 41 19. Gram, L. , Over", K. : Drug interaction: Inhibitory effect of neuroleptics on metabolism of tricyclic antidepressants in man. Brit. med. J. 1972 I, 463. 20. Guelen, P. J. : Statistical analysis of pharmacokinetic parameters in epileptic patients chronically treated with anti-epileptic drugs. In: Clinical Pharmacology of Anti-Epileptic Drugs (eds. H. Schneider, D.

Life Sciences 10, 1207 (1971). 9. , Gaylor, J. : Existence and separation of three forms of cytomrome P-450 rat liver microsomes. J. bioI. Chem. 248, 4947 (1973). 10. Davies, D. , Gigon, P. , Gilette, J. : Species and sex differences in electron transport systems in liver microsomes and their relationship to ethylmorphine demethylation. Life Sciences 8, 85 (1969). 11. Dayton, P. , Perel, J. : Physiological and physicodlemical bases of drug interaction in man. Ann. Y. Acad. Sci. 179,67 (1971). 12.

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