Clinical Management of Melanoma by Hilliard F. Seigler (auth.), H. F. Seigler (eds.)

By Hilliard F. Seigler (auth.), H. F. Seigler (eds.)

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J Bone Joint Surg 61A:276-280, 1979. 50. Mallar WG: A malignant melanotic tumor of ganglion cells arising from a thoracic sympathetic ganglion. J Pathol Bacteriol 35:351-357, 1932. 51. Kniseley RM and Baggenstoss AH: Primary melanoma of the adrenal glands. Arch Pathol 42: 345-349, 1946. 52. Dick JC, Titchie GM and Thompson H: Histological differentiation between pheochromocytoma and melanoma of the suprarenal gland. J Clin Pathol 8: 89-98, 1955. 53. Mandybur TI: Melanotic nerve sheath tumors. J Neurosurg 41:187-192,1974.

Clark had indicated that SSM and NM were rare on the palms, soles or nailbeds. Melanoma of mucous membranes Probably less than 5 % of melanomas begin in mucosal sites, but those that do devastate the patient. The most common site is the vulva, but other sites include the vagina, anus, penis, oral cavity, nose, sinuses, esophagus and conjunctiva [20]. Clark indicates that their histology is similar to that of ALM, but NM and SSM forms have also been reported. Some have a junctional component; others do not, but submucosal invasion is almost always present (Figures 8, 11).

Most appeared in the early 20th century literature and were "unassociated" with any primary tumor [98-101]. No patient, however, was examined with Wood's light, etc. for a primary melanoma which had regressed, and over half of the reported cases were bilateral and symmetrical. The adrenal glands usually retained a "normal configuration, " but were black and several times normal size. All patients rapidly succumbed to widespread disease. One case ofa pigmented adenoma has been described by Baker [103] in which the histologic morphology differed from that of a melanoma.

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