By Myrtle A. Davis
Univ. of Maryland, Baltimore. Discusses laser scanning cytometry for the research of apoptosis, tissue-based equipment of quantification for stories utilizing animal versions, and useful assays and ELISA strategies. DNLM: Apoptosis--physiology.
Read or Download Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification PDF
Similar toxicology books
The fundamental technology of the mobile and molecular responses of the mind to harm is a speedily increasing region of analysis that gives proof of turning out to be possibilities for pharmacological intervention within the health facility. CNS accidents: mobile Responses and Pharmacological recommendations is an updated exam of recent advancements in our knowing of the mobile and trophic responses to CNS accidents and the capability remedy.
Gad Consulting prone, Cary, NC. Serves as a pragmatic consultant for these chargeable for or fascinated about making sure defense within the use and manufacture of scientific units. Introduces present charts and knowledge for all elements of danger review. earlier version isn't really brought up. Expanded-outline layout.
Supplying an in-depth precis of the molecular features of carcinogenesis, this article comprehensively covers chemical, radiation, and viral carcinogenesis - from animal and human try out information to metabolism and DNA binding. It experiences natural and steel carcinogenesis concerning lung, breast, prostate, pores and skin, liver, colon, mind, and thyroid cancers.
Apprehensive process is within the so much circumstances a possible goal for the untoward results of chemical substances. the damaging effects impact essentially the person yet can also significantly pressure the total society. The intake of ethanol is a evident instance (National Institute on Alcohol Abuse and Alcoholism 1978).
- Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification
- Guidebook to Protein Toxins and Their Use in Cell Biology
- An introduction to immunotoxicology
- Toxicological Survey of African Medicinal Plants
- Advances in Microbial Food Safety: Volume 2
- Pharmacology And Toxicology of Amphetamine And Related Designer Drugs
Additional info for Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification
Smith, C. L, Nechushtan, A, Xi, X. , and Youle, R. J. (1997) Movement of Bax from the cytosol to mitochondria during apoptosis. J. Cell Biol. 139(5), 1281–1292. Mahajan, N. , Gordon, G. , and Herman, B. (1998) Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer [see comments]. Nat. Biotechnol. 16(6), 547–552. Qin, Z. , Kikly, K. , Kegel, K. , and DiFiglia, M. (2000) Pro-caspase-8 is Predominatly localized in mitochondria and released into cytoplasm upon apoptotic stimulation.
In 32D cells induced to undergo apoptosis through interleukin-3 (IL-3) withdrawal, total [Ca2+]i remained unaltered, although a significant subcellular redistribution of Ca2+ from the cytoplasm to the mitochondria occurred, which could be inhibited by Bcl-2 expression (52). Some Ca2+-sensitive fluorochromes (Rhod-2 and derivatives) are reported to selectively partition into mitochondria and may be capable of detecting a local change in mitochondrial calcium. Fluorescence microscopy can determine the specific subcellular compartment in which an alteration of [Ca2+]i takes place through co-localization of calcium probe fluorescence with the appropriate organelle-specific markers.
Am. J. Physiol. 276(1 Pt 1), G1–G6. 4. Warny, M. and Kelly, C. P. (1999) Monocytic cell necrosis is mediated by potassium depletion and caspase-like proteases. Am. J. Physiol. 276(3 Pt 1), C717–C724. 5. Raffray, M. and Cohen, G. M. (1997) Apoptosis and necrosis in toxicology: a continuum or distinct modes of cell death? Pharmacol. Ther. 75(3), 153–177. 6. Cotran, R. , and Robbins, S. L. (1999) Robbin’s Pathological Basis of Disease. W. B. Saunders, Philadelphia. 7. , and Kroemer, G. (1998) The central executioners of apoptosis: caspases or mitochondria?