Allergens and respiratory pollutants: The role of innate by Marc A. Williams

By Marc A. Williams

Pt. 1. floor amendment recommendations -- pt. 2. Analytical ideas and functions

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Extra resources for Allergens and respiratory pollutants: The role of innate immunity

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A major local allergic disease is asthma. Atopic or allergic asthma is a severe pulmonary disease affecting predominantly urban industrialized Western populations with well over 300 million individuals globally affected by the disease. Atopic asthma is often considered a disease of developed countries. Clinically, asthma is largely characterized by airway inflammation coupled with transient narrowing of the airways (bronchoconstriction), secretion and deposition of mucus in the airways, resulting in extreme difficulty in breathing, wheezing, repetitive cough and, in the severest form, coma and death.

3 Williams MA, Cheadle C, Watkins T, Tailor A, Killedar SY, Breysse P, Barnes K and Georas SN. (2007). TLR2 and TLR4 as potential biomarkers of environmental particulate matter exposed human myeloid dendritic cells. Biomarker Insights 2: 225–39. 4 Williams MA, Rangasamy T, Bauer SM, Killedar S, Karp M, Kensler TW, Yamamoto M, Breysse P, Biswal S and Georas SN. (2008). Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter.

Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter. J Immunol 181: 4545–59. 5 Rangasamy T, Williams MA, Bauer S, Trush MA, Emo J, Georas SN and Biswal S. (2010). Nrf2 inhibits the maturation of murine dendritic cells by ragweed extract. Am J Respir Cell Mol Biol 43: 276–85. 6 Bezemer GF, Bauer SM, Oberdörster G, Breysse PN, Pieters RH, Georas SN, Williams MA. (2010). Activation of pulmonary dendritic cells and Th2-type inflammatory responses on instillation of engineered, environmental diesel emission source or ambient air pollutant particles in vivo.

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