Algorithmen kurz gefasst by Uwe Schöning

By Uwe Schöning

In kompakter shape macht das Buch mit den wesentlichen Themen vertraut, die in einer Vorlesung ?ber Algorithmen behandelt werden. Im Mittelpunkt stehen dabei die verschiedensten sequentiellen Algorithmen, deren Komplexit?tsanalyse und allgemeine Algoithmen-Paradigma. Prof. Sch?ning gelingt es, kurz, konkret und verst?ndlich die wichtigsten algorithmischen Aufgabenstellungen (Selektion, Sortieren, Hashing), Algorithmen auf Graphen, algebraische und zahlentheoretische Verfahren zu behandeln. Hinzu kommen heuristische Algorithmenprinzipien wie z.B. genetisches Programmieren.

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Once polarized, the granules can be exocytosed to exert their cytotoxic effect. Reproduced with permission from Orange et al. (2006). Chapter 1: Basic science L2 ? HLA A+03 HLA Bw4 HLA Bw4 ? ? S3 S4 S5 L3 L4 L5 KIR2D HLA Cw4 S2 HLA G HLA Cw1/3/7/8 S1 L1 HLA Cw1/3/7/8 HLA Cw1/3/7/8 HLA Cw2/4/5/6 HLA Cw2/4/5/6 Human KIR family receptors and their ligands S1 L1 L2 L3 KIR3D Transmembrane domain ITIM Each of the 14 human KIRs is represented graphically. The KIR2D group having two Ig-like domains (represented by the ‘‘C’’ shaped loops) is shown on the left, and the KIR3D group having three Ig-like domains is shown on the right.

This status, in turn, is determined by the immune phenotype and cytogenetic abnormality present. Immune Phenotype of ALL Frequency (%) Type of ALL HLA-DR Tdt Pro-B-ALL Common ALL Pre-B-ALL B-ALL Early T-ALL T-ALL # þ þ þ þ 0 0 þ þ þ 0 þ þ CD10 CD19* CyIg SIg CD7† CyCD3 Adults Children 0 þ þ þ/– 0/þ 0/þ þ þ þ þ 0 0 0 0 0 þþ 0 0 0 0 0 0 þ þ 4–10 50–60 %10 3–4 7–10 15%– 20% 7 70 %15 2–3 %l %10 0 0 þ þ/– 0 0 0 0 0 0 þ þ (þCD1a, CD2, CD3) CD ¼ cluster of differentiation (see page 11): CyIg ¼ cytoplasmic immunoglobulin, SIg ¼ surface immunoglobulin, CyCD3 ¼ cytoplasmic CD3.

Many conventional chemotherapy protocols for ALL currently stratify treatment according to risk status. This status, in turn, is determined by the immune phenotype and cytogenetic abnormality present. Immune Phenotype of ALL Frequency (%) Type of ALL HLA-DR Tdt Pro-B-ALL Common ALL Pre-B-ALL B-ALL Early T-ALL T-ALL # þ þ þ þ 0 0 þ þ þ 0 þ þ CD10 CD19* CyIg SIg CD7† CyCD3 Adults Children 0 þ þ þ/– 0/þ 0/þ þ þ þ þ 0 0 0 0 0 þþ 0 0 0 0 0 0 þ þ 4–10 50–60 %10 3–4 7–10 15%– 20% 7 70 %15 2–3 %l %10 0 0 þ þ/– 0 0 0 0 0 0 þ þ (þCD1a, CD2, CD3) CD ¼ cluster of differentiation (see page 11): CyIg ¼ cytoplasmic immunoglobulin, SIg ¼ surface immunoglobulin, CyCD3 ¼ cytoplasmic CD3.

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