Advances in Molecular Toxicology, Vol. 2 by James C. Fishbein

By James C. Fishbein

Advances in Molecular Toxicology positive factors the most recent advances in all the subspecialties of the wide region of molecular toxicology. Toxicology is the research of toxins and this sequence info the research of the molecular foundation wherein an unlimited array of brokers encountered within the human atmosphere and produced via the human physique itself occur themselves as pollution. no longer strictly restricted to documenting those examples the sequence is usually serious about the advanced net of chemical and organic occasions that provide upward thrust to toxin-induced indicators and sickness. the hot applied sciences which are being harnessed to investigate and comprehend those occasions can also be reviewed by means of major employees within the box. Advances in Molecular Toxicology will record growth in all elements of those speedily evolving molecular points of toxicology with a view towards certain elucidation of either growth at the molecular point and on advances in technological methods hired * leading edge studies via major employees within the self-discipline. * intensive dissection of molecular elements of curiosity to a vast diversity of scientists, physisicans and any scholar within the allied disciplines. * innovative functions of technological techniques within the chemistry, biochemistry and molecular medication.

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D. A. Dombrowski, Iron(II) EDTA used to measure the helical twist along any DNA molecule, Science 230 (1985) 679–681. M. Meijler, O. S. Sigman, Chemical mechanism of DNA scission by (1,10-phenanthroline)copper. Carbonyl oxygen of 5-methylenefuranone is derived from water, J. Am. Chem. Soc. 119 (1997) 1135–1136. P. J. A. E. U. M. Baker, Chromium(V)induced cleavage of DNA: are chromium(V) complexes the active carcinogens in chromium(VI)-induced cancers? Chem. Res. Toxicol. 2 (1989) 227–229. D. Sugden, Formation of modified cleavage termini from the reaction of chromium(V) with DNA, J.

These considerations indicate that covalent binding to proteins is indeed an important biomarker reflecting the presence of potentially harmful reactive metabolites. 1. Bioactivation of troglitazone and other thiazolidinedione drugs The mechanisms of troglitazone-induced hepatotoxicity are not fully understood and seem to be multifactorial [18], one of the potential factors being the formation of reactive metabolites after enzyme-mediated bioactivation. Clinical and postmarketing surveillance indicated that troglitazone-induced hepatotoxicity was not a characteristic of TZD drugs in general although isolated case reports of hepatotoxic events for rosiglitazone and pioglitazone exist [29,30].

Rev. 87 (1987) 1107–1136. N. S. Fonkeng, Mechanisms of DNA damage by chromium carcinogens, J. Chem. Soc. Chem. Commun. 18 (1996) 2211–2212. N. K. M. Hagen, Oxidants, antioxidants and the degenerative disease of aging, Proc. Natl. Acad. Sci. A. 90 (1993) 7915–7922. [60] H. Kasai, S. Nishimura, in: H. ), Oxidative Stress: Oxidants and Antioxidants, Academic Press, Ltd, London, 1991, pp. 99–116. B. N. Ames, Oxidative decay of DNA, J. Biol. Chem. 272 (1997) 19633–19636. N. L. Saul, Oxidative DNA damage, cancer and aging, Ann.

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