Advances in Low-Temperature Biology, Volume 3 by Peter L. Steponkus

By Peter L. Steponkus

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1992), red blood cell (RBC) count, hematocrit and hemoglobin decreased following the procedure but returned to the normal range by three days in Group II compared with three weeks in Group I. White blood cells (WBC) were more highly elevated in Group I, returning to the normal range in the second week, compared with the small change in Group II, which normalized within three days postoperatively. Levels of serum enzymes that are recognized indicators of tissue function were monitored for up to three weeks post-operatively in the surviving dogs.

1985; 1989)). With reference again to the earlier attempts by Kondo et al.

Subsequent Phase II studies were designed to examine Hypothermic Protection During Bloodless Surgery the role and nature of the hypothermic blood substitutes per se in a standardized procedure derived from these Phase I experiments. Phase II: New Aqueous Blood Substitutes for Brain Protection and in situ Tissue Preservation during Profound Hypothermic Cardiac Arrest The concept of UHBS is appealing for several reasons: deeper hypothermia can provide more effective suppression of metabolism, thereby extending the tolerance to ischemia and minimizing the demand for oxygen to levels that can be adequately supplied in a cold aqueous solution without the need for special oxygencarrying molecules.

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